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Campo DC | Valor | Idioma |
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dc.contributor.author | Gomes, Alice de Freitas | - |
dc.date.available | 2023-11-08 | - |
dc.date.available | 2023-11-21T13:08:00Z | - |
dc.date.issued | 2023-07-16 | - |
dc.identifier.uri | http://repositorioinstitucional.uea.edu.br//handle/riuea/5345 | - |
dc.description.abstract | Leukemia represents a group of hematologic malignancies that originate from stem cells, causing the proliferation and accumulation of leukocytes in the bone marrow and blood. In 2018, leukemia was ranked the 15th most common cancer worldwide and the 11th leading cause of death. Nanoparticles as drug carriers offer advantages such as the ability to specifically target cancer cells, reduce treatment toxicity, and increase drug efficacy. The aim of this study was to evaluate the anticancer and immunomodulatory activity of bismuth nanoparticles and the nanoparticle containing crajiru (nanoparticle-CRJ) in myeloid leukemia cell lines. All tests were performed in vitro, using the HL60 (acute myeloid leukemia) and K562 (chronic myeloid leukemia) cancer cell lines, and non-cancer Vero cell lines and peripheral blood monoclonal cells (PBMC) from blood donors. The cytotoxic activity of the nanoparticles was evaluated using the MTT test, while the ability to inhibit the clonal expansion of cancer cells was investigated using the colony formation assay. To evaluate the immunomodulatory potential, pro-inflammatory and anti-inflammatory cytokines were measured by means of an immunoenzymatic assay (ELISA) in supernatant of PBMC treated with nanoparticles. The results showed that both the CRJ and Bismuth nanoparticle showed significant cytotoxic activity against the cancer cell lines HL60 (p<0.05) and K562 (p< 0.05) at all tested concentrations when compared to the control (untreated cells). No significant cytotoxic activity of the nanoparticle-CRJ was observed in non-cancer cells. The bismuth nanoparticle showed cytotoxic activity in non-cancer cells, reducing cell viability by an average of 27%, but less than that of cancer cells which reduced by an average of 43%. The bismuth nanoparticle reduced the formation of HL60 cell colonies by 79%, while the CRJ-nanoparticle reduced it by 93.95%. Regarding K562 cells, the nanoparticle-CRJ totally inhibited the formation of colonies. The nanoparticle-CRJ induced the expression of cytokines IL-6, IL-10, IL-12 and TNF-α, which demonstrates its immunomodulatory potential. The results of this study indicate that the bismuth nanoparticle has an anticancer potential, while the CRJ-nanoparticle has an anticancer and immunomodulatory potential. These data suggest that these compounds are promising candidates for prospective studies in the treatment of myeloid leukemia | pt_BR |
dc.language | por | pt_BR |
dc.publisher | Universidade do Estado do Amazonas | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.subject | Leucemia | pt_BR |
dc.subject | Imunomodulação | pt_BR |
dc.subject | Nanopartpiculas | pt_BR |
dc.subject | Citotoxidade | pt_BR |
dc.title | Compostos nanoparticulados : avaliação do potencial antileucêmico e imunomodulador | pt_BR |
dc.title.alternative | Nanoparticulate compounds : evaluation of antileukemic and immunomodulatory potential | pt_BR |
dc.type | Dissertação | pt_BR |
dc.date.accessioned | 2023-11-21T13:08:00Z | - |
dc.contributor.advisor-co1 | Grafov, Andriy | - |
dc.contributor.advisor-co1Lattes | http://lattes.cnpq.br/6700085891416715 | pt_BR |
dc.contributor.advisor1 | Pontes, Gemilson Soares | - |
dc.contributor.advisor1Lattes | http://lattes.cnpq.br/9081671233815990 | pt_BR |
dc.contributor.referee1 | Pontes, Gemilson Soares | - |
dc.contributor.referee1Lattes | http://lattes.cnpq.br/9081671233815990 | pt_BR |
dc.contributor.referee2 | Mariúba, Luís André Morais | - |
dc.contributor.referee2Lattes | http://lattes.cnpq.br/4784959431673419 | pt_BR |
dc.contributor.referee3 | Quintão, Jerusa Araújo | - |
dc.creator.Lattes | GOMES, A. F.;DE FREITAS GOMES, ALICE | pt_BR |
dc.description.resumo | A leucemia representa um grupo de neoplasias hematológicas que têm origem nas células-tronco, causando a proliferação e acúmulo de leucócitos na medula óssea e no sangue. Em 2018, a leucemia foi mundialmente classificada como o 15º câncer mais frequente e a 11ª principal causa de mortalidade. As nanopartículas como carreadores de medicamentos oferecem vantagens, como a capacidade de se direcionar especificamente às células cancerosas, reduzir a toxicidade do tratamento e aumentar a eficácia do medicamento. O objetivo deste estudo foi avaliar a atividade anticancerígena e imunomoduladora de nanopartículas de bismuto e a nanopartícula contendo crajiru (nanopartícula-CRJ) em linhagens celulares de leucemia mieloide. Todos os testes foram realizados in vitro, utilizando as linhagens cancerígenas HL60 (leucemia mieloide aguda) e K562 (leucemia mieloide crônica), e as células não cancerígenas da linhagem Vero e células monoclueares do sangue períferico (PBMC) de doadores de sangue. A atividade citotóxica das nanopartículas foi avaliada por meio do teste MTT, enquanto que capacidade de inibir a expansão clonal de células cancerígenas foi investigada por meio do ensaio de formação de colônias. Para avaliar o potencial imunomodulador, citocinas pro-inflamatórias e anti-inflamatórias foram dosadas por meio de um ensaio imunoenzimático (ELISA), em sobrenadante de PBMC tratadas com as nanopartículas. Os resultados demonstraram que tanto a nanopartícula-CRJ quanto a de Bismuto apresentaram atividade citotóxica significativa contra as linhagens cancerígenas HL60 (p<0.05) e K562 (p< 0.05) em todas as concentrações testadas quando comparado ao controle (células não tratadas). Não foi observada atividade citotóxica significativa da nanopartícula-CRJ em células não cancerígenas. A nanopartícula de bismuto apresentou atividade citotóxica em células não-cancerígenas, reduzindo a viabilidade das células em uma média de 27%, porém menor do que em relação às células cancerígenas que reduziram em uma média de 43%. A nanopartícula de bismuto reduziu a formação de colônias de células HL60 em 79%, enquanto que a nanopartícula-CRJ reduziu em 93,95%. Em relação às células K562, a nanopartícula-CRJ inibiu totalmente a formação de colônias. A nanopartícula-CRJ induziu a expressão das citocinas IL-6, IL-10, IL-12 e TNF-α, o que demonstra seu potencial imunomodulador. Os resultados deste estudo indicam que a nanopartícula de bismuto apresenta um potencial anticancerígeno, enquanto a nanopartícula-CRJ possui potencial antincancerígeno e imunomodulador. Estes dados sugerem que esses compostos são candidatos promissores para estudos prospectivos no tratamento de leucemia mielóide | pt_BR |
dc.publisher.country | Brasil | pt_BR |
dc.publisher.program | PPGH -PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS APLICADAS À HEMATOLOGIA | pt_BR |
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