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dc.contributor.authorCastro, Arthur Junio de Moraes-
dc.date.available2020-03-18-
dc.date.available2020-03-17T19:13:48Z-
dc.date.issued2014-05-29-
dc.identifier.urihttp://repositorioinstitucional.uea.edu.br//handle/riuea/2356-
dc.description.abstractGametocytes are essential for the transmission of malaria endemicity of the disease and thus are targets for malaria control strategies. The prevalence of individuals infected with Plasmodium vivax gametocytes that carreiam remains poorly characterized in endemic areas. This study aimed to estimate the prevalence and factors associated with carrying of sexual forms of P. falciparum and P. vivax in participants with asymptomatic and symptomatic infection in an endemic area of malaria in the Brazilian Amazon. We perform a cut with 2072 participants residing in peri-urban area of Manaus-AM city with questionnaires and collection of blood samples for the detection of malarial infection qPCR method, and sexual forms of P. vivax, the RT technique -qPCR. From the data gathered and molecular results was possible to establish the prevalence and factors associated with infection and carrying of gametocytes of P. vivax, univariade analysis. The prevalence of P. vivax infection was 3.38% and gametocitemia was 1.64%. The prevalence of P. vivax infection in asymptomatic gametocitemia and corresponded to 67.14% of this parasite (47/70) and 61.76% (21/34), respectively, with low density circulating parasites (37, 62 copies / uL). Factors associated with malaria infection were: recent malaria (OR = 3.07; 95% CI = 1.18 to 7.95; p = 0.21), recent use of antimalarial (OR = 3.41; 95% CI = 1.57 to 7.37; p <0.0001), and the presence of fever (OR = 6.90; 95% CI = 3.67 to 12.99; p <0.0001). The protection factors for infection with P. vivax were: gender, age and malaria history. Factors associated with the carrying of gametocytes of P. vivax malaria were: recent (OR = 4.98, 95% CI 1.80 to 15.62; p = 0.011), recent use of antimalarial (OR = 4.57; 95% CI = 1.72 to 12.13, p = 0.009), location (OR = 2.84, 95% CI 1.08 to 7.44; p = 0.034), presence of fever (OR = 6.60; 95% CI 2.79 to 15.63; p <0.001) and previous infection presenting as higher risk for gametocitemia of P. vivax in the category 4-10 infections (OR = 18.40; 95% CI = 2, 42 to 193.93, p <0.001). The age group above 15 years was the only risk factor for entrainment of gametocytes of P. vivax in asymptomatic (OR = 33.25, 95% CI 3.90 to 283.46; p = 0.001). In this study, the carrying of gametocytes in asymptomatic infections by P. vivax epidemiological relevance and evidence suggests interventions in malaria control. The longitudinal studies are needed to determine the contribution to the long-term infection in asymptomatic patients with low density gametocytes, which are left undiagnosed and untreated. Keywords: Malaria, Gametocytes, RT-qPCR, Plasmodium vivax.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade do Estado do Amazonaspt_BR
dc.rightsAcesso Abertopt_BR
dc.rightsAtribuição-NãoComercial-SemDerivados 3.0 Brasil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectMaláriapt_BR
dc.subjectGametócitospt_BR
dc.subjectRT-qPCRpt_BR
dc.subjectPlasmodium vivaxpt_BR
dc.titlePrevalência do carreamento de formas sexuais de Plasmodium falciparum e Plasmodium vivax em uma área endêmica, no município de Manaus, Amazonaspt_BR
dc.typeDissertaçãopt_BR
dc.date.accessioned2020-03-17T19:13:48Z-
dc.contributor.advisor-co1Lacerda, Marcus Vinícius Guimarães de-
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/8492376468047417pt_BR
dc.contributor.advisor1Tadei, Wanderli Pedro-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/6806722604010480pt_BR
dc.contributor.referee1Tadei, Wanderli Pedro-
dc.contributor.referee1Latteshttp://lattes.cnpq.br/6806722604010480pt_BR
dc.contributor.referee2Guerra, Maria das Graças Vale Barbosa-
dc.contributor.referee2Latteshttp://lattes.cnpq.br/2940481324985304pt_BR
dc.contributor.referee3Monteiro, Wuelton Marcelo-
dc.contributor.referee3Latteshttp://lattes.cnpq.br/4986967857234820pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/6746140373317521pt_BR
dc.description.resumoGametócitos são essenciais para a transmissão da malária e endemicidade da doença, assim são alvos para estratégias de controle da malária. A prevalência de indivíduos infectados por Plasmodium vivax que carreiam gametócitos permanece mal caracterizado em áreas endêmicas. Este trabalho teve como objetivo estimar a prevalência e fatores associados ao carreamento de formas sexuais de P. falciparum e P. vivax em participantes com infecção assintomática e sintomática em uma área endêmica de malária na Amazônia Brasileira. Realizamos um corte com 2072 participantes, residentes em área periurbana da cidade Manaus-AM, com aplicação de questionários e coleta de amostras de sangue para detecção de infecção malárica pelo método de qPCR, e de formas sexuais de P. vivax, pela técnica de RT-qPCR. A partir dos dados apurados e dos resultados moleculares foi possível estabelecer as prevalências e os fatores associados à infecção e ao carreamento de gametócitos de P. vivax, utilizando análise univariade. A prevalência de infecção por P. vivax foi de 3,38% e de gametocitemia foi de 1,64%. A prevalência de infecção por P. vivax e da gametocitemia em assintomáticos correspondeu a 67,14% do total deste parasito (47/70) e 61,76% (21/34), respectivamente, com baixa densidade de parasitos circulantes (37,62 cópias/µL). Os fatores associados à infecção malárica foram: malária recente (OR=3,07; IC 95%=1,18-7,95; p=0,21), uso recente de antimalárico (OR=3,41; IC 95%=1,57-7,37; p<0,0001), e presença de febre (OR=6,90; IC 95%=3,67-12,99; p<0,0001). Os fatores de proteção para a infecção por P. vivax foram: gênero, faixa etária e histórico de malária. Os fatores associados ao carreamento de gametócitos de P. vivax foram: malária recente (OR=4,98; IC95%=1,80-15,62; p=0,011), uso recente de antimalárico (OR=4,57; IC95%=1,72-12,13; p=0,009), localidade (OR=2,84; IC95%=1,087,44; p=0,034), presença de febre (OR=6,60; IC95%=2,79-15,63; p<0,001) e infecção prévia apresentando-se como maior risco para a gametocitemia de P. vivax, na categoria 4-10 infecções (OR=18,40; IC95%=2,42-193,93; p<0,001). A faixa etária acima de 15 anos foi o único fator de risco para carreamento dos gametócitos de P. vivax em assintomáticos (OR=33,25; IC95%=3,90-283,46; p=0,001). Neste estudo, o carreamento de gametócitos em infecções assintomáticas por P. vivax evidencia relevância epidemiológica e sugere intervenções no controle de malária. A realização de estudos longitudinais se faz necessária para determinar a contribuição para a infecção de longa duração em portadores assintomáticos com baixa densidade de gametócitos, os quais são deixados sem diagnóstico e tratamento. Palavras-chave: Malária, Gametócitos, RT-qPCR, Plasmodium vivax.pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.programPrograma de Pós-Graduação em Biotecnologia e Recursos Naturaispt_BR
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dc.subject.cnpqBiotecnologiapt_BR
dc.publisher.initialsUEApt_BR
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