Estudo químico e avaliação da atividade biológica de extratos de Minquartia guianensis AUBL. (OLACACEAE)

Abstract

Plants produce a wide variety of substances that can be used to generate drugs. Among the species of occurrence in the Amazon is Minquartia guianensis. Previous results stimulated new chemical investigations and the evaluation of new biological activities with this species. Therefore, the aim of this study was the chemical study of the methanol extracts of the 1st and 2nd branches collect and to evaluate the extracts for the activities of toxicity against Artemia salina, antibacterial, antifungal, angiogenic and antimalarial. Thus, the plant material (branches and leaves) were dried, grounded and extracted with dichloromethane, methanol and distilled water. As results obtained, the extracts were active on Artemia salina (100% mortality in concentration at the concentration of 1000 μg / mL). As for the antibacterial activity tested by the microdilution methodology, the methanolic extract of the branches had a minimum inhibitory concentration (MIC) of 1000 μg / mL against the bacteria Escherichia coli and Pseudomonas aeruginosa. In relation to the antifungal activity of the phases of the methanolic extract of the branches, the hydromethanolic phase presented MICs of 200 μg / mL and 800 μg / mL against Cryptococcus neoformans and Candida albicans, respectively, and the ethyl acetate phase had a MIC of 400 μg / mL against C. albicans. All the extracts tested, except the dichloromethane extract of the leaves presented antimalarial activity. All the extracts showed antiangiogenic activity, being higher the potential of the aqueous extract of the leaves.

Keywords: Biological activities; antimicrobial; angiogenesis; antimalarial.