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dc.contributor.authorPaz, Andréia da Costa-
dc.date.available2020-03-13-
dc.date.available2020-03-13T14:13:03Z-
dc.date.issued2018-03-27-
dc.identifier.urihttp://repositorioinstitucional.uea.edu.br//handle/riuea/2278-
dc.description.abstractZika virus (ZIKV) causes an arbovirose with widespread worldwide distribution transmitted to humans by the bite of females of infected mosquitoes. Ae. aegypti and Ae. albopictus are considered the main vectors, being widely distributed particularly in the tropical region where the virus is prevalent. Although Ae. albopictus is typical of wild environments, this species is also found adapted to the urban environment. In Manaus its occurrence has been recorded since 2002, however its role in the ZIKV transmission dynamics is unknown. To be considered a good vector the mosquito must have vector competence, which involves the susceptibility of the mosquito to become infected by a virus, to replicate it and to transmit it. Studies on the vectorial competence of the genus Aedes for the ZIKV are wide, but with divergent results. For Ae. albopictus in Brazil, only one study was carried out with a population of Rio de Janeiro, and there was no information on the vectorial competence of this species in the city of Manaus. This work aimed to evaluate the vectorial competence of a population of Aedes albopictus from the city of Manaus to the ZIKV. The work was carried out in the entomology laboratory of the Tropical Medicine Foundation. Females of Ae. albopictus were exposed to the virus through artificial feeding and, for comparison purposes, a population of Ae. aegypti was used as control group. Rates of virus infection and dissemination were analyzed through the body and head by RT-qPCR, after dissection on the 7th, 14th and 21st day post-infection. Transmission analysis to determine vector competence occurred on the 14th day post-infection from saliva collection and quantification by RTqPCR. The population of Ae. albopictus from Manaus was susceptible to infection with ZIKV, presenting values similar to that observed for the control group formed by a population of Ae. aegypti evaluated on the same days post infection. It presented infection rates of 65% in the 7th dpi and 70% in the 14th and 21st dpi. The rates of disseminated infection were 23% in the 7th dpi, 57% in the 14th and 14% in the 21dpi. Vector competence was 30% in the 7th dpi, 40% in the 14th and 10% in the 21st. Transmission of the virus was observed in 30% of the 10 Ae. albopictus analyzed. The results obtained in this study demonstrated that the Ae. albopictus from Manaus is susceptible to ZIKV, allowing replication over the post-infection days; infection rates were high and similar to that observed for Ae. aegypti, the main vector of the ZIKV in the world. In addition to being susceptible, Ae. albopictus also showed that the virus had spread to the salivary glands, demonstrating that the population of Ae. albopictus in the city of Manaus presents the vectorial competence as vector of the Zika virus. The great geographic distribution and the high adaptability of Ae. albopictus make their transmission potential an indication of attention as the outbreak of ZIKV continues. Keywords: Arbovirose, susceptibility, viral replication, competence, vector.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade do Estado do Amazonaspt_BR
dc.rightsAcesso Abertopt_BR
dc.rightsAtribuição-NãoComercial-SemDerivados 3.0 Brasil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectArbovirosept_BR
dc.subjectSuscetibilidadept_BR
dc.subjectReplicação viralpt_BR
dc.subjectCompetênciapt_BR
dc.subjectVetorpt_BR
dc.titleAvaliação da competência vetorial de populações de Aedes albopictus de Manaus, Amazonas ao Zika Víruspt_BR
dc.typeDissertaçãopt_BR
dc.date.accessioned2020-03-13T14:13:03Z-
dc.contributor.advisor-co1Pimenta, Paulo Filemon Paolucci-
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/4592140991723664pt_BR
dc.contributor.advisor1Guerra, Maria das Graças Vale Barbosa-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/2940481324985304pt_BR
dc.contributor.referee1Guerra, Maria das Graças Vale Barbosa-
dc.contributor.referee1Latteshttp://lattes.cnpq.br/2940481324985304pt_BR
dc.contributor.referee2Tadei , Vanderli Pedro-
dc.contributor.referee3Mourão, Maria Paula Gomes-
dc.contributor.referee3Latteshttp://lattes.cnpq.br/6752341165899077pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/2101031358422239pt_BR
dc.description.resumoO Zika vírus (ZIKV) causa uma arbovirose com ampla distribuição mundial transmitida ao homem pela picada de fêmeas de mosquitos infectados. Ae. aegypti e Ae. albopictus são considerados os principais vetores, por serem amplamente distribuídas particularmente na região tropical onde o vírus é prevalente. Embora Ae. albopictus seja típico de ambientes silvestres, esta espécie também é encontrada adaptada ao ambiente urbano. Em Manaus sua a ocorrência é registrada desde 2002, contudo não se sabe o seu papel na dinâmica de transmissão do ZIKV. Para ser considerado um bom vetor o mosquito deve apresentar competência vetorial, que envolve a suscetibilidade do mosquito em tornar-se infectado por um vírus, replicá-lo e transmiti-lo. Estudos sobre a competência vetorial do gênero Aedes para o ZIKV são amplos, porém com resultados divergentes. Para Ae. albopictus, no Brasil, apenas um estudo foi realizado com uma população do Rio de Janeiro, não havendo informações sobre a competência vetorial dessa espécie na cidade de Manaus. Este trabalho teve como objetivo avaliar a competência vetorial de uma população de Aedes albopictus da cidade de Manaus ao ZIKV. O trabalho foi realizado no laboratório de entomologia da Fundação de Medicina Tropical. Fêmeas de Ae. albopictus foram expostas ao vírus através de alimentação artificial e, para fins de comparação, uma população de Ae. aegypti foi utilizada como grupo controle. As taxas de infecção e disseminação do vírus foram analisadas através do corpo e cabeça, por RT-qPCR, após dissecção no 7º, 14º e 21º dia pósinfecção (dpi). A análise da transmissão para determinação da competência vetorial ocorreu no 14º dia pós-infecção a partir da coleta da saliva e quantificação por RT-qPCR. A população de Ae. albopictus de Manaus se mostrou suscetível a infecção ao ZIKV apresentando valores similares ao observado para o grupo controle formado por uma população de Ae. aegypti, avaliado nos mesmos dias pós infecção. Apresentou taxas de infecção de 65% no 7º dpi e 70% no 14º e 21ºdpi. As taxas de infecção disseminada foram de 23% no 7º dpi, 57% no 14º e 14% no 21ºdpi. A competência vetorial foi de 30% no 7º dpi, 40% no 14º e 10% no 21ºdpi. A transmissão do vírus foi observada em 30% dos 10 espécimes de Ae. albopictus analisadas. Os resultados obtidos neste estudo demostraram que a população de Ae. albopictus de Manaus é suscetível ao ZIKV, permitindo replicação ao longo dos dias pós-infecção; as taxas de infecção foram altas e similares ao observado para Ae. aegypti, principal vetor do ZIKV no mundo. Além de ser suscetível, Ae. albopictus demonstrou ainda que houve a disseminação do vírus até as glândulas salivares, demonstrando que a população de Ae. albopictus na cidade de Manaus apresenta a competência vetorial como vetor do Zika vírus. A grande distribuição geográfica e a alta adaptabilidade de Ae. albopictus tornam o seu potencial de transmissão um indicativo de atenção à medida que o surto de ZIKV continua. Palavras-chave: Arbovirose, suscetibilidade, replicação viral, competência, vetor.pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.programPrograma de Pós-Graduação em Biotecnologia e Recursos Naturaispt_BR
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PLOS Neglected Tropical Diseases, v. 7, n. 8, p. e2448. 2013. YE, Q. et al. Infection , Genetics and Evolution Genomic characterization and phylogenetic analysis of Zika virus circulating in the Americas. MEEGID, v. 43, p. 43–49, 2016. ZANLUCA, C. et al. First report of autochthonous transmission of Zika virus in Brazil. Memorias do Instituto Oswaldo Cruz, v. 110, n. 4, p. 569–572, 2015. ZARA, A. L. S. A. et al. Estratégias de controle do Aedes aegypti: uma revisão. Epidemiol. Serv. Saúde, v. 25, n. 2, p. 391-404, abr-jun. 2016.pt_BR
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dc.publisher.initialsUEApt_BR
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